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gluconeogenesis II (Methanobacterium thermoautotrophicum)

State Icon Reaction EC-Number Confidence maximal confidence score from EnzymeDetector
HCO3- <=> H2O + CO2 1.6.5.4 monodehydroascorbate reductase (NADH)
4.2.1.1 carbonic anhydrase


phosphate + oxaloacetate <=> phosphoenolpyruvate + HCO3- 4.1.1.31 phosphoenolpyruvate carboxylase

D-glyceraldehyde_3-phosphate + H2O + oxidized_ferredoxin <=> 3-phospho-D-glycerate + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.6 glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)

D-fructose_1,6-bisphosphate <=> dihydroxyacetone_phosphate + D-glyceraldehyde_3-phosphate 4.1.2.13 fructose-bisphosphate aldolase
4.1.2.40 tagatose-bisphosphate aldolase


beta-D-fructose_6-phosphate + ADP <=> H+ + D-fructose_1,6-bisphosphate + AMP 2.7.1.146 ADP-specific phosphofructokinase

2-phospho-D-glycerate <=> 3-phospho-D-glycerate 5.4.2.11 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)
5.4.2.12 phosphoglycerate mutase (2,3-diphosphoglycerate-independent)


H2O + pyruvate + ATP <=> H+ + phosphate + phosphoenolpyruvate + AMP 2.7.1.40 pyruvate kinase
2.7.9.2 pyruvate, water dikinase


D-glucose_6-phosphate <=> beta-D-fructose_6-phosphate 2.6.1.16 glutamine---fructose-6-phosphate transaminase (isomerizing)
5.3.1.8 mannose-6-phosphate isomerase
5.3.1.9 glucose-6-phosphate isomerase



pyruvate + CoA + oxidized_ferredoxin <=> acetyl-CoA + CO2 + reduced_ferredoxin_[iron-sulfur]_cluster + H+ 1.2.7.1 pyruvate synthase
1.2.7.11 2-oxoacid oxidoreductase (ferredoxin)
1.2.7.7 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)



pyruvate + ATP <=> H+ + phosphoenolpyruvate + ADP 2.7.1.40 pyruvate kinase

2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O 4.2.1.11 phosphopyruvate hydratase

pyruvate + HCO3- + ATP <=> H+ + oxaloacetate + ADP + phosphate 6.4.1.1 pyruvate carboxylase

D-glyceraldehyde_3-phosphate <=> dihydroxyacetone_phosphate 5.3.1.1 triose-phosphate isomerase

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